Researcher Database

UEHARA RYO

Department / Course College of Life Sciences Department of Biotechnology

Title / Position Assistant Professor

Papers
1.	2022/04	Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function. │ Scientific reports │ 12 (1),pp.6674 (Co-authored)
2.	2022/04	MEK/ERK-mediated oncogenic signals promote secretion of extracellular vesicles by controlling lysosome function. │ Cancer science │ 113 (4),pp.1264-1276 (Co-authored)
3.	2021/02	Insertion loop-mediated folding propagation governs efficient maturation of hyperthermophilic Tk-subtilisin at high temperatures. │ FEBS letters │ 595 (4),pp.452-461 (Co-authored)
4.	2020/09	Crystal structure of a GH1 β-glucosidase from Hamamotoa singularis. │ Protein science : a publication of the Protein Society │ 29 (9),pp.2000-2008 (Co-authored)
5.	2020/02	Crystal structures of the cell-division protein FtsZ from Klebsiella pneumoniae and Escherichia coli. │ Acta crystallographica. Section F, Structural biology communications │ 76 (Pt 2),pp.86-93 (Co-authored)
6.	2020	Val143 of human ribonuclease H2 is not critical for, but plays a role in determining catalytic activity and substrate specificity. │ PloS one │ 15 (2),pp.e0228774 (Co-authored)
7.	2019/08	Unlike the Escherichia coli counterpart, archaeal RNase HII cannot process ribose monophosphate abasic sites and oxidized ribonucleotides embedded in DNA. │ The Journal of biological chemistry │ 294 (35),pp.13061-13072 (Co-authored)
8.	2019/05	Aicardi-Goutières syndrome gene Rnaseh2c is a metastasis susceptibility gene in breast cancer. │ PLOS Genetics │ 15 (5),pp.e1008020 (Co-authored)
9.	2018/10	Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development. │ Cell Reports │ 25 (5),pp.1135-1145 (Co-authored)
10.	2013/12	Formation of the high-affinity calcium binding site in pro-subtilisin E with the insertion sequence IS1 of pro-Tk-subtilisin. │ Biochemistry │ 52 (50),pp.9080-9088 (Co-authored)
11.	2013/10	Increase in activation rate of Pro-Tk-subtilisin by a single nonpolar-to-polar amino acid substitution at the hydrophobic core of the propeptide domain. │ Protein Science │ 22 (12),pp.1711-1721 (Co-authored)
12.	2013/02	Accelerated maturation of Tk-subtilisin by a Leu→Pro mutation at the C-terminus of the propeptide, which reduces the binding of the propeptide to Tk-subtilisin. │ FEBS Journal │ 280 (4),pp.994-1006 (Co-authored)
13.	2012/11	Requirement of insertion sequence IS1 for thermal adaptation of Pro-Tk-subtilisin from hyperthermophilic archaeon. │ Extremophiles │ 16 (6),pp.841-851 (Co-authored)
14.	2012/06	Requirement of Ca2+ Ions for the Hyperthermostability of Tk-subtilisin from Thermococcus kodakarensis. │ Biochemistry │ 51 (26),pp.5369-5278 (Co-authored)