研究者学術情報データベース

フジタ　タクヤ
藤田　卓也
FUJITA Takuya

所属薬学部薬学科

職名教授

論文
1.	2022/11	Inhibition of Liquid–Liquid Phase Separation for Breaking the Solubility Barrier of Amorphous Solid Dispersions to Improve Oral Absorption of Naftopidil. │ Pharmaceutics │ 14 (12),2664 (共著)
2.	2022/08	Alleviative effects of glutamate against chemotherapeutics agent-induced intestinal mucositis. │ Journal of Physiology and Pharmacology │ 73 (4),539-546頁 (共著)
3.	2022/07/01	Mesenchymal stem cells promote IL-6 secretion and suppress the gene expression of proinflammatory cytokines in contractile C2C12 myotubes │ Biological and Pharmaceutical Bulletin │ 45 (7),962-967頁 (共著)
4.	2022/05/18	Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System. │ Cells │ 11 (10),1677 (共著)
5.	2022/02/15	Prediction of oral drug absorption in rats from in vitro data. │ Pharmaceutical Research │ ,in press (共著)
6.	2021/12/21	The Development of Biomimetic Aligned Skeletal Muscles in a Fully 3D Printed Microfluidic Device. │ Biomimetics │ 7 (1),2 (共著)
7.	2021/10/27	Intramuscular injection of mesenchymal stem cells activates anabolic and catabolic systems in mouse skeletal muscle. │ Scientific Reports │ 11 (1),21224 (共著)
8.	2021/10/16	Generation of Caco-2 cells stably expressing CYP3A4·POR·UGT1A1 and CYP3A4·POR·UGT1A1*6 using a PITCh system. │ Archives of Toxicology │ 96 (2),499-510頁 (共著)
9.	2021/05/07	Indigo enhances wound healing activity of Caco‑2 cells via activation of the aryl hydrocarbon receptor. │ Journal of Natural Medicines │ 75 (4),833-839頁 (共著)
10.	2021/03/15	Characterization of P-glycoprotein inhibitors for evaluating the effect of P-glycoprotein on the intestinal absorption of drugs. │ Pharmaceutics │ 13,388 (共著)
11.	2021/02/05	Relevance of Liquid-liquid Phase Separation of Supersaturated Solution in Oral Absorption of Albendazole from Amorphous Solid Dispersions. │ Pharmaceutics │ 13 (2),20 (共著)
12.	2021/01/30	Magnetization of mesenchymal stem cells using magnetic liposomes enhances their retention and immunomodulatory efficacy in mouse inflamed skeletal muscle. │ International Journal of Pharmaceutics │ 596,120298 (共著)
13.	2020/12/01	Prediction of negative food effect induced by bile micelle binding on oral absorption of hydrophilic cationic drugs. │ European Journal of Pharmaceutical Sciences │ 155,105543 (共著)
14.	2020/11/01	Mesenchymal stem cells after the inflammatory response of C2C12 mouse skeletal muscle cells. │ Biological and Pharmaceutical Bulletin │ 43 (11),1785-1791頁 (共著)
15.	2020/09/03	Bottom-up physiologically-based oral absorption modeling of free weak base drugs. │ Pharmaceutics │ 12 (9),844 (共著)
16.	2020/06	Hepatic expression of the Na⁺-coupled citrate transporter (NaCT/Slc13a5) and cellular uptake of citrate in a mouse model of type 1 diabetes induced by streptozotocin. │ BPB Reports │ 3 (3),97-101頁 (共著)
17.	2020/06	The impact of breast cancer resistance protein (BCRP/ABCG2) on drug transport across Caco-2 cell monolayers │ Drug Metabolism and Disposition │ 48 (6),491-498頁 (共著)
18.	2020/04/09	Transport characteristics of 5-aminosalicylic acid into colonic epithelium: Involvement of sodium-coupled monocarboxylate transporter SMCT1-mediated transport system. │ Biochemical and Biophysical Research Communications │ 524 (3),561-566頁 (共著)
19.	2020/04/01	Transport characteristics of 5-aminosalicylic acid derivatives conjugated with amino acids via human H⁺-coupled oligopeptide transporter PEPT1. │ Biological and Pharmaceutical Bulletin │ 43 (4),697-706頁 (共著)
20.	2020/04	Impact of degree of supersaturation on the dissolution and oral absorption behaviors of griseofulvin amorphous solid dispersions. │ Journal of Drug Delivery Science and Technology │ 56,101172 (共著)
21.	2020/03	Prediction characteristics of oral absorption simulation software evaluated using structurally diverse low solubility drugs. │ Journal of Pharmaceutical Sciences │ 109 (3),1403-1416頁 (共著)
22.	2020/01	Assessment of contribution of BCRP to intestinal absorption of various drugs using portal-systemic blood concentration difference model in mice. │ Pharmacological Research and Perspective │ 8 (1),e00544 (共著)
23.	2019/12	Enhanced macrophage delivery to the colon using magnetic lipoplexes with a magnetic field. │ Drug Delivery │ 26 (1),935-943 (共著)
24.	2019/12	Protein kinase C regulates the citrate transport via Na⁺-coupled citrate transporter NaCT in HepG2 cells. │ BPB Reports │ 2 (6),134-140頁 (共著)
25.	2019/08/05	Harmonizing solubility measurement to lower inter-laboratory variance - progress of consortium of biopharmaceutical tools (CoBiTo) in Japan. │ ADMET DMPK │ 7 (3),183-195頁 (共著)
26.	2019/08	Prediction Accuracy of Mechanism-Based Oral Absorption Model for Dogs. │ Journal of Pharmaceutical Sciences │ 108 (8),2728-2736 (共著)
27.	2019/05	An Openable Artificial Intestinal Tract System Enables the Evaluation of Drug Absorption in Caco-2 Cells through the Reduction in Thickness of the Unstirred Water Layer. │ Biological and Pharmaceutical Bulletin │ 42 (5),840-844 (共著)
28.	2018/07	Pharmaceutical stability of colloidal saccharated iron oxide injection in normal saline. │ Journal of Pharmaceutical Health Care and Sciences │ 4,Article number: 21 (共著)
29.	2018/01	Effect of surface charge, particle size, and modification by polyethylene glycol of liposomes on their association with Caco-2 cells across an unstirred water layer. │ Pharmazie │ 73 (1),3-8 (共著)
30.	2017/12	Influence of physicochemical properties and PEG modification of magnetic liposomes on their interaction with intestinal epithelial Caco-2 Cells. │ Biological and Pharmaceutical Bulletin │ 40 (12),2166-2174 (共著)
31.	2017/11	Development of magnetic anionic liposome/atelocollagen complexes for efficient magnetic drug targeting. │ Drug Delivery │ 24 (1),1740-1749 (共著)
32.	2017/01	Pharmacokinetic modeling and Monte Carlo simulation to predict interindividual variability in human exposure to oseltamivir and its active metabolite, Ro 64-0802. │ The AAPS Journal │ 19 (1),286-297 (共著)
33.	2016/11	Dextran sodium sulfate alters cytokine production in macrophages in vitro. │ Pharmazie │ 71 (11),619-624 (共著)
34.	2016/08	Effect of mechanical agitation on cationic liposome transport across an unstirred water layer in Caco-2 cells. │ Biological and Pharmaceutical Bulletin │ 39 (8),1293-1299 (共著)
35.	2015/08	An openable artificial intestinal tract system for the in vitro evaluation of medicines. │ Microsystems &Nanoengineering │ 1,15015 (共著)
36.	2013/01	Studies on the Intestinal Absorption Characteristics of Sulfasalazine, a Breast Cancer Resistance Protein (BCRP) Substrate. │ Drug Metabolism and Pharmacokinetics │ 28 (1),71-74 (共著)
37.	2012/07	Pharmacokinetic interaction study of sulfasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP. │ British Journal of Pharmacology │ 166 (6),1793-1803 (共著)
38.	2012/02	Extra-renal Elimination of Uric Acid via Intestinal Efflux Transporter BCRP/ABCG2. │ PLoS ONE │ 7 (2),e30456 (共著)
39.	2011/12	Quantitative evaluation of the impact of active efflux by P-gp and Bcrp at the BBB on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as surrogate. │ Journal Pharmacology and Experimental Therapeutics │ 339 (3),935-944 (共著)
40.	2011/06	Intranasal immunization with poly(γ-glutamic acid) nanoparticles entrapping antigenic proteins can induce potent tumor immunity. │ Journal of Controlled Release │ 152 (2),310-316 (共著)
41.	2010/11	Absorption and safety of alendronate, a nitrogen-containing bisphosphonate, after intrapulmonary administration in rats. │ International Journal of Pharmaceutics │ 400 (1-2),124-130頁 (共著)
42.	2009/12	Amino acids suppress apoptosis induced by sodium laurate, an absorption enhancer. │ Journal of Pharmaceutical Sciences │ 98 (12),4629-4638頁 (共著)
43.	2008/12	Modulating effect of polyethylene glycol on the intestinal transport and absorption of prednisolone, methylprednisolone and quinidine in rats by in-vitro and in-situ absorption studies. │ Journal of Pharmacy and Pharmacology │ 60 (12),1633-1644頁 (共著)
44.	2008/11	Oligoarginine-based prodrugs with self-cleavable spacers for intestinal absorption. │ Chemical and Pharmaceuticsl Bulletin │ 56 (11),1515-1520 (共著)
45.	2008/10	A transcutaneous vaccination system using a hydrogel patch for viral and bacterial infection │ Journal of Cotrolled Release │ 131 (2),113-120 (共著)
46.	2008/07	Improvement of intestinal absorption of insulin and water-soluble macromolecular compounds by chitosan oligomers in rats │ International Journal of Pharmaceutics │ 359 (1-2),70-78 (共著)
47.	2008/05	Factors involved in the maturation of murine dendritic cells transduced with adenoviral vector variants. │ Viology │ 374 (2),411-420 (共著)
48.	2008/04	Improvement of intestinal absorption of water-soluble macromolecules by various polyamines: Intestinal mucosal toxicity and absorption-enhancing mechanism of spermine. │ International Jouranl of Pharmaceutics │ 354 (1-2),126-134 (共著)
49.	2008/03	Functional characterization and cloning of amino acid transporter B^0,+ (ATB^0,+) in primary cultured rat pneumocytes. │ Journal of Cellular Physiology │ 214 (3),645-654頁 (共著)
50.	2008/02	P-glycoprotein restricts the penetration of oseltamivir across the blood-brain barrier │ Drug Metabolism and Disposition │ 36 (2),427-434頁 (共著)
51.	2008/01	Creation and X-ray structure analysis of the tumor necorsis factor receptor-1 selective mutant of a TNF-α antagosist. │ 283 (2),998-1007 (共著)
52.	2008/01	Oseltamivir (Tamiflu^TM) efflux transport at the blood-brain barrier via P-glycoprotein │ Drug Metabolism and Disposition │ 36 (1),6-9頁 (共著)
53.	2007/11	CC-chemokine ligand 17 gene therapy induces tumor regression through augmentation of tumor-infiltrating immune cells in a murine model of pre-existing CT26 colon carcinoma. │ International Journal of Cancer │ 121,2013-2022 (共著)
54.	2007/11	Interaction of penton base Arg-Gly-Asp motifs with integrins is crucial for adenovirus serotype 35 vector transduction in human hematopoietic cells. │ Gene Therapy │ 14,1525-1533 (共著)
55.	2007/09	Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers towards effective intestinal absorption. │ Bioorganic and Medicinal Chemistry Letters │ 17,5129-5132 (共著)
56.	2007/09	Improvement of pulmonary absorption of inuslin and other water-soluble compounds by polyamines in rats. │ Journal of Controlled Release │ 122,94-101 (共著)
57.	2007/01	102 Creation of TNF receptor1 selective mutant TNF using phage display syste. │ Cytokine │ 39 (1),28 (共著)
58.	2006/06	Excellent absorption enhancing characteristics of NO donors for improving the intestinal absorption of poorly absorbable compound compared with conventional absorption enhancers. │ Drug Metabolism and Pharmacokinetics │ 21 (3),222-229 (共著)
59.	2006/06	Identity of the high-affinity sodium/carboxylate cotransporter NaC3 as the N-acetyl-L-aspartate transporter. │ Advances in Experimental Medicine and Biology │ 576,67-76頁 (共著)
60.	2006/06	What kinds of substrates show P-glycoprotein- dependent intestinal absorption? Comparison of verapamil with vinblastine. │ Drug Metabolism and Pharmacokinetics │ 21 (3),238-244 (共著)
61.	2006/04	Colon-specific delivery and enhanced colonic absorption of [Asu^1,7] Eel calcitonin using chitosan capsules containing various additives in rats. │ Journal of Drug Targeting │ 14 (3),165-172 (共著)
62.	2006/04	Functional and molecular identification of sodium- coupled dicarboxylate transporters in primary cultured cerebrocortical astrocytes and neurons. │ Journal of Neurochemistry │ 97 (1),162-173頁 (共著)
63.	2006/04	Functional characterization of Na⁺-coupled citrate transporter NaC2/NaCT expressed in primary cultures of neurons from mouse cerebral cortex. │ Brain Research │ 1081 (1),92-100頁 (共著)
64.	2006/04	Functional expression of taurine transporter and its up-regulation in developing neurons from mouse cerebral cortex. │ Pharmaceutical Research │ 23 (4),689-696頁 (共著)
65.	2006/04	Modulation of intestinal P-glycoprotein function by polyethylene glycols and their derivatives by in vitro transport and in situ absorption studies. │ International Journal of Pharmaceutics │ 313 (1),49-56 (共著)
66.	2006/04	Tumor suppressive efficacy through augmentation of tumor-infiltrating immune cells by intratumoral injection of chemokine-expressing adenoviral vector. │ Cancer Gene Therapy │ 13 (4),393-405 (共著)
67.	2006/03	Functional expression of metabotropic γ-aminobutyric acid GABA_B receptor in primary culture of astrocytes from rat cerebral cortex. │ Biochemical and Biophysical Research Communications │ 341 (3),874-881頁 (共著)
68.	2006/02	Functional characterization of Zn²⁺-sensitive GABA transporter expressed in primary cultures of astrocytes from rat astrocytes. │ Brain Research │ 1075 (1),99-108頁 (共著)
69.	2006/01	Functional characteristics of H⁺-dependent nicotinic acid transport in primary cultures of astrocytes from rat cerebral cortex. │ Neuroscience Letters │ 392 (3),207-212 (共著)
70.	2006/01	Functional characterization of Na⁺-independent choline transport in primary cultures of neurons from mouse cerebral cortex. │ Neuroscience Letters │ 393 (2-3),216-221 (共著)
71.	2005/11	Chitosan oligomers as potential and safe absorption enhnacers for improving the pulmonary absorption of interferon-α in rats. │ Journal of Pharmaceutical Sciences │ 94 (11),2432-2440 (共著)
72.	2005/09	Nitric oxide donors can enhance the intestinal transport and absorption of insulin and [Asu^1,7]-eel calcitonin in rats. │ Journal of Controlled Release │ 106 (3),283-293 (共著)
73.	2005/05	A Prostacyclin analog prevents radiocontrast nephropathy via phosphorylation of cyclic AMP response element binding protein. │ American Journal of Pathology │ 166 (5),1333-1342頁 (共著)
74.	2005/05	Functional linkage of H⁺/peptide transporter PEPT2 and Na⁺/H⁺ exchanger in primary cultures of astrocytes from mouse cerebral cortex. │ Brain Research │ 1044 (1),31-41頁 (共著)
75.	2005/05	Transport characteristics of N-acetyl-L-aspartate in rat astrocytes: Involvement of sodium-coupled high affinity carboxylate transporter NaC3/NaDC3 mediated transport system. │ Journal of Neurochemistry │ 93 (3),706-714頁 (共著)
76.	2005/04	Carrageenans can regulate the pulmonary absorption of antiasthmatic drugs and their retention in the rat lung tissues without any membrane damage. │ International Journal of Pharmaceutics │ 293 (1-2),63-72 (共著)
77.	2005/04	Functional characterization and adaptive regulation of Na⁺-dependent neutral amino acid transporter SNAT2/ATA2 in normal human astrocytes under amino acid starved condition. │ Neuroscience Letters │ 378 (2),70-75頁 (共著)
78.	2005/04	Functional regulation of Na⁺-dependent neutral amino acid transporter ASCT2 by S-nitrosothiols and nitric oxide in human intestinal cell line Caco-2. │ FEBS Letters │ 579 (11),2499-2506頁 (共著)
79.	2005/04	Improvement of absorption enhancing effects of n-dodecyl-β-D-malto-pyranoside by its colon-specific delivery using chitosan capsules. │ International Journal of Pharmaceutics │ 293 (1-2),127-135 (共著)
80.	2005/01	Augmentation of the migratory ability of DC-based vaccine into regional lymph nodes by efficient CCR7 gene transduction. │ Gene Therapy │ 12 (2),129-139 (共著)
81.	2005/01	Immunological properties and vaccine efficacy of murine dendritic cells simultaneously expressing melanoma- associated antigen and interleukin-12. │ Cancer Gene Therapy │ 12 (1),72-83 (共著)
82.	2004/09	Control of pulmonary absorption of water-soluble compounds by various viscous vehicles. │ International Journal of Pharmaceutics │ 282 (1-2),141-149 (共著)
83.	2004/04	Anti-tumor activity of chemokine is affected by both kinds of tumors and the activation state of the host's immune system: implications for chemokine-based cancer immunotherapy. │ Biochemical and Biophysical Research Communications │ 317 (1),68-76 (共著)
84.	2004/04	Functional expression of constitutive nitric oxide synthase regulated by voltage-gated Na⁺- and Ca²⁺- channels in cultured human astrocytes. │ Glia │ 46 (1),53-62頁 (共著)
85.	2004/04	Modulation of intestinal P-glycoprotein function by cremophor EL and other surfactants by an in vitro diffusion chamber method using the isolated rat intestinal membranes. │ Journal of Pharmaceutical Sciences │ 93 (4),877-885 (共著)
86.	2004/01	Functional characterization of brain peptide transporter in rat cerebral cortex: Identification of the high affinity type H⁺/peptide transporter PEPT2. │ Brain Research │ 997 (1),52-61頁 (共著)
87.	2003/10	Dendritic cells transduced with gp100 gene by RGD fiber-mutant adenovirus vectors are highly efficacious in generating anti-B16BL6 melanoma immunity in mice. │ Gene Therapy │ 10 (22),1891-1901 (共著)
88.	2003/06	Gabapentin blocks L-type and P/Q-type Ca²⁺ channels involved in depolarization- stimulated nitric oxide synthase activity in primary culture of neurons from mouse cerebral cortex. │ Pharmaceutical Research │ 26 (6),1365-1367頁 (共著)
89.	2003/06	Intradermal concentration of hydroquinone after application of hydroquinone ointments is higher than its cytotoxic concentration. │ Biological and Pharmaceutical Bulletin │ 26 (6),1365-1367 (共著)
90.	2003/05	A comparison of Ca²⁺ channel blocking mode between gabapentin and verapamil: Implication for protection against hypoxic injury in rat cerebrocortical slices. │ British Journal of Pharmacology │ 139 (2),435-443 (共著)
91.	2003/05	Gene transduction efficiency and maturation status in mouse bone marrow-derived dendritic cells infected with conventional or RGD fiber- mutant adenovirus vectors. │ Cancer Gene Therapy │ 10 (5),421-431 (共著)
92.	2003/01	Effects of various storage conditions and alterations of antioxidant contents on chromatic aberration of hydroquinone ointment. │ Biological and Pharmaceutical Bulletin │ 26 (1),120-122 (共著)
93.	2003/01	Enhanced permeability of phenylalanyl-glycine (Phe-Gly) across the intestinal membranes by chemical modification with various fatty acids. │ Drug Metabolism and Pharmacokinetics │ 18 (1),23-32 (共著)
94.	2003/01	Enhanced transdermal delivery of phenylalanyl- glycine by chemical modification with various fatty acids. │ International Journal of Pharmaceutics │ 250 (1),119-128 (共著)
95.	2002/10	Halothane attenuates the cerebroprotective action of several Na⁺- and Ca²⁺- channel blockers via reversal of their ion channel blockade. │ European Journal of Pharmacology │ 452 (2),175-181頁 (共著)
96.	2002/04	Chitosan capsules for colon-specific drug delivery: enhanced localization of 5-aminosalicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats. │ Journal of Controlled Release │ 82 (1),51-61 (共著)
97.	2002/03	Tumor necrosis factorα‐gene therapy for an established murine melanoma using RGB (Arg‐Gly‐Asp) fiber‐mutant adenovirus vectors │ Cancer Science │ 93 (4),436-444 (共著)
98.	2002/01	Pharmaceutical and clinical assessment of hydroquinone ointment prepared by extemporaneous nonsterile compounding. │ Biological and Pharmaceutical Bulletin │ 25 (1),92-96 (共著)
99.	2001/11	Efficient antigen gene transduction using Arg-Gly-Asp fiber-mutant adenovirus vectors can potentiate antitumor vaccine efficacy and maturation of murine dendritic cells. │ Cancer Research │ 61 (21),7913-7919 (共著)
100.	2001/10	Absorption of water-soluble compounds with different molecular weights and [Asu^1,7]-eel calcitonin from various mucosal administration sites. │ Journal of Controlled Release │ 76 (3),364-373 (共著)
101.	2001/08	Effects of lipofection-antigen complexes on major histocompatibility comples class I-restricted antigen presentation pathway in murine dendritic cells and on dendritic cell maturation. │ Biochimica et Biophysica Acta │ 1527 (1),97-101 (共著)
102.	2001/06	Administration route- dependent vaccine efficiency of murine dendritic cells pulsed with antigens. │ British Journal of Cancer │ 84 (11),1564-1570 (共著)
103.	2001/06	Role of nuclear factor-κB in gastric ulcer healing in rats. │ American Journal of Physiology- Gastrointestinal and Liver Physiology │ 280 (6),G1296-G1304 (共著)
104.	2001/05	Involvement of transporter recruitment as well as gene expression in the substrate- induced adaptive regulation of amino acid transport system A. │ Biochimica et Biophysica Acta │ 1512 (1),15-21 (共著)
105.	2001/04	Evaluation of insulin permeability and effects of absorption enhancers on its permeability by an in vitro pulmonary epithelial system using Xenopus pulmonary membrane. │ Biological and Pharmaceutical Bulletin │ 24 (4),378-384 (共著)
106.	2001/03	Efficient gene delivery into dendritic cells by fiber-mutant adenovirus vectors. │ Biochemical and Biophysical Research Communications │ 282 (1),173-176 (共著)
107.	2001/01	Enhanced absorption of insulin and (Asu^1,7)eel- calcitonin using novel azopolymer-coated pellets for colon-specific drug delivery. │ Journal of Pharmaceutical Sciences │ 90 (1),89-97 (共著)
108.	2001/01	FR167653, a p38 mitogen- activated protein kinase inhibitor, prevents Helicobacter pylori-induced gastritis in Mongolian gerbils. │ Journal of Pharmaceology and Experimental Therapeutics │ 296 (1),48-56 (共著)
109.	2001/01	Modulation of intestinal permeability by nitric oxide donors: implications in intestinal delivery of poorly absorbable drugs. │ Journal of Pharmacology and Experimental Therapeutics │ 296 (1),84-90 (共著)
110.	2000/12	Development of novel lipophilic derivatives of DADLE (leucine enkephaline analogue): Intestinal permeability characteristics of DADLE derivatives in rats. │ Pharmaceutical Research │ 17 (12),1461-1467 (共著)
111.	2000/10	NSAID-induced acute gastric injury in Helicobacter pylori gastritis in Mongloian gerbils. │ European Journal of Pharmacology │ 406 (3),461-468 (共著)
112.	2000/10	Role of cyclooxygenase-2 in Helicobacter pylori-induced gastritis in Mongolian gerbils. │ American Journal of Physiology- Gastrointestinal and Liver Physiology │ 279 (4),G791-G798 (共著)
113.	2000/06	Electrophysilogical characteristics of Caco-2 cells using microelectrode: Application to evaluate the absorption enhancers. │ Biological and Pharmaceutical Bulletin │ 23 (6),738-742 (共著)
114.	2000/01	Colon-specific delivery of peptide drugs and anti- inflammatory drugs using chitosan capsules. │ S.T.P. Pharmacy and Sciences │ 10 (1),23-34 (共著)
115.	1999/11	Enhanced permeability of insulin across the rat intestinal membrane by various absorption enhancers: Their intestinal mucosal toxicity and absorption enhancing mechanism of n-lauryl-beta-D-maltopyranoside. │ Journal of Pharmacy and Pharmacology │ 51 (11),1241-1250 (共著)
116.	1999/10	Validation of pharmacokinetic model for colon-specific drug delivery system and therapeutic effects of chitosan capsules containing 5-aminosalicylic acid on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in rats. │ Journal of Pharmacy and Pharmacology │ 51 (10),1107-1112 (共著)
117.	1999/08	Electrophysiological study on enhanced mechanism of intestinal transport of water-soluble compounds by antibiotic peptide bacitracin. │ Biological and Pharmaceutical Bulletin │ 22 (8),841-845 (共著)
118.	1999/08	Interaction of kyotorphin and brain peptide transporter in synaptosomes prepared from rat cerebellum: Implication of high affinity type H⁺/peptide transpoorter PEPT2 mediated transport system. │ Neuroscience Letters │ 271 (2),117-120 (共著)
119.	1999/08	Sigma receptor ligand- induced up-regulation of the H⁺/peptide transporter PEPT1 in the human intestinal cell line Caco-2. │ Biochemical and Biophysical Research Communications │ 261 (2),242-246 (共著)
120.	1999/06	Development of an oral formulation of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, using n-lauryl-beta-D-maltopyranoside as an absorption enhancer. │ Biological and Pharmaceutical Bulletin │ 22 (6),611-615 (共著)
121.	1999/05	Colon-specific delivery of budesonide with azopolymer-coating pellets: Therapeutic effects of budesonide with a novel dosage form against 2,4,6-trinitrobenzenesulfonic acid-induced ulcerative colitis in rats. │ Journal of Phamacy and Pharmacology │ 51 (5),257-261 (共著)
122.	1999/03	Colon specific delivery of R68070, a new thromboxane synthase inhibitor, using chitosan capsules: Therapeutic effects of 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats. │ Life Sciences │ 64 (13),1155-1162 (共著)
123.	1999/03	Transport kinetics of leucine-enkephalin across Caco-2 monolayer: Quantitative analysis for contribution of enzymatic and transport barriers. │ Life Sciences │ 64 (14),1243-1252 (共著)
124.	1998/09	Permeability characteristics of acyl-tetragastrins across the intestinal membranes using the Caco-2 monolayer system. │ Pharmaceutical Research │ 15 (9),1387-1392 (共著)
125.	1998/08	Effects of various protease inhibitors on the stability and permeability of [D-Ala², D-Leu⁵]enkephalin in the rat intestine: Comparison with leucin enkephalin. │ Journal of Pharmaceutica Sciences │ 87 (8),448-452 (共著)
126.	1998/08	Use of protease inhibitors to improve calcitonin absorption from the small and large intestine in rats. │ Journal of Pharmacy and Pharmacology │ 50 (8),913-920 (共著)
127.	1998/06	Effectiveness and toxicity screening of various absorption enhancers using Caco-2 cell monolayers. │ Biological and Pharmaceutical Bulletin │ 21 (6),615-620 (共著)
128.	1998/06	Two oligopepite transporters from Caenorhabditis elegans. molecular cloning and functional expression. │ Biochemical Journal │ 332 (2),565-572 (共著)
129.	1998/05	Identification of a potential substrate binding domain in the mammalian peptide transporters PEPT1 and PEPT2 using PEPT1-PEPT2 and PEPT2-PEPT1 chimeras. │ Biochemical and Biophysical and Research Communications │ 246 (1),39-44 (共著)
130.	1998/03	Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate. │ Journal of Biological Chemistry │ 273 (13),7501-7506 (共著)
131.	1998/02	Exon-intron structure, analysis of promoter region, and chromosomal localization of the human type I sigma receptor gene. │ Journal of Neurochemistry │ 70 (2),443-451 (共著)
132.	1997/12	Enhancement of the small intestinal uptake of phenylalanylglycine via a H⁺/oligopeptide transport system via chemical modification with fatty acids. │ Life Sciences │ 61 (25),2455-2465 (共著)
133.	1997/08	Metabolism of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, by intestinal microorganism. │ Pharmaceutical Research │ 14 (8),1004-1007 (共著)
134.	1997/05	Pharmacokinetic analysis of scavenger receptor-mediated uptake of anionized proteins in the isolated perfused rat liver. │ International Journal of Pharmaceutics │ 151 (1),15-26 (共著)
135.	1997/05	Pharmacokinetics of mitomycin C (MMC) after intraperitoneal administration of MMC-gelatin gel and its anti-tumor effects against Sarcoma-180 bearing mice. │ Journal of Drug Targeting │ 4 (5),289-296 (共著)
136.	1997/05	Potential for lymphatic targeting of peptides. │ Journal of Controlled Release │ 46 (1-2),157-164 (共著)
137.	1997/02	Degradation of insulin and calcitonin and their protection by various protease inhibitors in rat cecal contents: Implications in peptide delivery to the colon. │ Journal of Pharmacy and Pharmacology │ 49 (2),164-168 (共著)
138.	1997/02	Selective delivery of 5-fluorouracil (5-FU) to i.p. tissues using 5-FU microspheres in rat. │ Anti-Cancer Drugs │ 8 (2),182-188 (共著)
139.	1997/01	Calcein is excreted from the intestinal mucosal cell membrane by the active transport system. │ Life Sciences │ 60 (4-5),307-313 (共著)
140.	1996/12	Effectiveness and toxicity screening of various absorption enhancers in the large intestine: Intestinal absorption of phenol red and protein and phospholipid release from the intestinal membrane. │ Biological and Pharmaceutical Bulletin │ 19 (12),1618-1621 (共著)
141.	1996/11	Pharmacological effects of 5-fluorouracil microspheres on peritoneal carcinomatosis in animals. │ British Journal of Cancer │ 74 (9),1392-1396 (共著)
142.	1996/08	Absorption enhancement effects of protease inhibitors on the absorption of phenol red and fluorescein isothiocyanate dextrans from the small and large intestine in rats. │ Journal of Pharmaceutical Sciences │ 85 (8),858-862 (共著)
143.	1996/08	Enhancement of intestinal transport of throtropin-releasing hormone via a carrier-mediated transport system by chemical modification with lauric acid. │ Biochimica Biophysica et Acta │ 1283 (1),119-126 (共著)
144.	1996/08	Pulmonary absorption enhancement of peptides by absorption enhancers and protease inhibitors. │ Journal of Controlled Release │ 41 (1-2),57-67 (共著)
145.	1996/08	Transport of drugs across the Xenopus pulmonary membrane and their absorption enhancement by various absorption enhancers. │ Pharmaceutical Research │ 13 (8),1257-1261 (共著)
146.	1996/05	(博士取得論文)物理化学的特性の修飾に基づくタンパク質医薬品の体内動態制御に関する研究 │ (単著)
147.	1996/05	Imrovement of intestinal absorption of human calcitonin by chemical modification with fatty acids: synergenic effects of acylation and absorption enhancers. │ International Journal of Pharmacetics │ 134 (1-2),47-54 (共著)
148.	1996/05	Lymphatic transfer of macromolecules after intrapulmonary administration in the presence or absence of various absorption enhancers in rats. │ Pharmazie │ 51 (5),331-336 (共著)
149.	1996/02	Effectiveness and toxicity screening of various absorption enhancers in the small intestine: Effect of absorption enhancers on the intestinal absorption of phenol red and the release of protein and phospholipid from the intestinal membrane. │ Journal of Pharmacy and Pharmacology │ 48 (2),1285-1289 (共著)
150.	1995/11	Molecular weight-dependent lymphatic transfer of fluorescein isothiocyanate-labeled dextrans after intrapulmonary administration and effect of various absorption enhancers on the lymphatic transfer of drugs in rats. │ Journal of Drug Targeting │ 3 (4),263-271 (共著)
151.	1995/10	Improvement of transdermal delivery of tetragastrin by lipophilic modification with fatty acids. │ Journal of Pharmacy and Pharmacology │ 47 (10),808-811 (共著)
152.	1995/08	Control of disposition characteristics of proteins by direct cationization. │ Pharmaceutical Sciences │ 1 (8),371-375 (共著)
153.	1995/08	Synergistic anti-tumor effects of mitomycin C and bile salts against L1210 cells. │ Biological and Pharmaceutical Bulletin │ 18 (8),1109-1113 (共著)
154.	1995/07	Intestinal absorption of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue. II. In situ and in vitro absorption characteristics of azetirelin from the rat intestine. │ Biological and Pharmaceutical Bulletin │ 18 (7),976-979 (共著)
155.	1995/06	Absorption characteristics of chemically modified-insulin derivatives with various fatty acids in the small and large intestine. │ Journal of Pharmaceutical Sciences │ 84 (6),682-687 (共著)
156.	1995/06	Metabolisms of peptide drugs by the microorganisms in rat cecal contents. │ Biological and Pharmaceutical Bulletin │ 18 (6),929-931 (共著)
157.	1995/06	Susceptibility of insulin to proteolysis in rat lung homogenate and its protection from proteolysis by various protease inhibitors. │ Biological and Pharmaceutical Bulletin │ 18 (6),891-894 (共著)
158.	1995/05	Comparison of permeability of macromolecular drugs across clutured intestinal and alveolar epithelial monolayers. │ Pharmaceutical Sciences │ 1 (5),231-234 (共著)
159.	1995/05	Does bacitracin have an absorption-enhancing effect in the intestine? │ Biological and Pharmaceutical Bulletin │ 18 (5),794-796 (共著)
160.	1994/12	Enhancement permeability of tetragastrin across the intestinal membrane and its reduced degradation by acylation with various fatty acids in rats. │ Journal of Pharmacology and Experimental Therapeutics │ 271 (3),1509-1513 (共著)
161.	1994/10	Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats. │ Pharmaceutical Research │ 11 (10),1496-1500 (共著)
162.	1994/09	Intestinal Absorption of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue I: Possible factors for the low bioavailability in rats. │ Biological and Pharmaceutical Bulletin │ 17 (9),1256-1261 (共著)
163.	1994/08	Stability of novel acyl derivatives of insulin in the small intestine: Relative importance of insulin association characteristics in aqueous solution. │ Pharmaceutical Research │ 11 (8),1115-1120 (共著)
164.	1994/07	Susceptibility of ebiratide to proteloysis in rat intestinal fluid and homogenates and its protection by various protease inhibitors. │ Life Sciences │ 55 (9),677-683 (共著)
165.	1994/04	Pharmacokinetics of succinylated proteins and dextran sulfate in mice: Implications for hepatic targeting of protein drugs by direct succinylation via scavenger receptors. │ International Journal of Pharmaceutics │ 105 (1),19-29 (共著)
166.	1994/02	Control of in vivo fate of albumin utilizing combined chemical modification. │ Journal of Drug Targeting │ 2 (2),157-165 (共著)
167.	1993/10	Development of new lipophilic derivatives of tetragastrin: Physicochemical characteristics and intestinal absorption of acyl-tetragastrin derivatives in rats. │ Pharmaceutical Research │ 10 (10),1488-1492 (共著)
168.	1993/03	Synthesis and pharmacokinetics of a new liver-specific carrier, glycosylated carboxylmethyl-dextran, and its application to drug targeting. │ Pharmaceutical Research │ 10 (3),1253–1261 (共著)
169.	1992/12	Targeted delivery of human recombinant superoxide dismutase by chemical modification with mono- and polysaccharide derivatives. │ Journal of Pharmacology and Experimental Therapeutics │ 263 (3),1847-1854 (共著)
170.	1992/11	Therapeutic effects of superoxide dismutase derivatives modified with mono- or polysaccharides on hepatics injury induced by ischemia/reperfusion. │ Biochemical and Biophysical Research Communications │ 189 (3),191-196 (共著)
171.	1992/09	Pharmacokinetics of receptor-mediated hepatic uptake of glycosylated albumin in mice. │ International Journal of Pharmaceutics │ 85 (1-3),75-85 (共著)
172.	1991/11	Tissue distribution of ¹¹¹In-labeled uricase conjugates with charged dextrans and polyethylene glycol. │ Journal of Pharmacobio-Dynamics │ 14 (11),623-629 (共著)
173.	1990/07	Biochemical and biopharmaceutical properties of macromolecular conjugates of uricase with dextran and polyethylene glycol. │ Chemical and Pharmaceutical Bulletin │ 38 (7),2053-2056 (共著)
174.	1990/04	Disposition characteristics of macromolecules in tumor-bearing mice. │ Pharmaceutical Research │ 7 (4),339-346 (共著)
175.	1990/01	Alteration of biopharmaceutical properties of drugs by their conjugation with water-soluble macromolecules: Uricase-dextran conjugates. │ Journal of Controlled Release │ 11 (1-3),149-156 (共著)
176.	1989/03	Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran II: Biopharmaceutical and pharmacological properties. │ Journal of Pharmaceutical Sciences │ 74 (3),219-222 (共著)
177.	1989/02	Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran I: Synthesis and characterization. │ Journal of Pharmaceutical Sciences │ 74 (2),117-121 (共著)