Researcher Database

（Last updated : 2021-10-26 13:55:42）　

WEN XIAOPENG

Department / Course College of Pharmaceutical Sciences Department of Pharmaceutical Sciences

Title / Position Assistant Professor

Academic background
1.	2015/04～2019/03	Doctorial Course │ Integrated Medical Science │ Graduate School, Division of Medicine │ Kyoto Prefectural University of Medicine │ Completed Doctor of Philosophy
2.	2013/04～2015/03	Master Course │ Medical Science │ Graduate School, Division of Medicine │ Kyoto Prefectural University of Medicine │ Completed Master of Medical Science
3.	2007/09～2011/07	Faculty of Pharmaceutical Science │ Guangdong Pharmaceutical University │ Graduated Bachelor of Pharmacy

Academic background

2015/04～2019/03

2013/04～2015/03

2007/09～2011/07

Business career
1.	2021/05/20 ～	Visiting Assistant Professor │ Kamei Group │ Kyoto University iCeMS Institute for Integrated Cell-Material Sciences
2.	2021/04 ～	Assistant Professor │ College of Pharmaceutical Sciences │ Ritsumeikan University
3.	2019/04 ～ 2021/03	Research Assistants │ The Kamei Group │ Institute for Integrated Cell-Material Sciences

Business career

2021/05/20 ～

2021/04 ～

2019/04 ～ 2021/03

Research activities
1.	2019/04 ～	The Japanese Pharmacological Society

Research activities

2019/04 ～

The Japanese Pharmacological Society

Subject of research
1.	Synucleinopathies and enteric nerves

Subject of research

Synucleinopathies and enteric nerves

Research summary
Development of an enterocytes-neuron co-culture system and synucleinopathy mechanism clarification Synucleinopathy, such as Parkinson's disease and dementia with Lewy bodies, are neurodegenerative diseases in various factors, such as inflammation and oxidative stress, cause aggregation of alpha-synuclein in neurons, leading to neuronal cell death. Aggregation of α-synuclein in nerves is associated with intestinal microbes and inflammation of the gut, and the onset of Parkinson's disease is presumed to be from gut. Clarify the pathology of synucleinopathy in the gut mucosa and its nerves, leading to develop the prevention and early treatment of synucleinopathy. The application of induced pluripotent stem cells (iPSC) has been widely used to elucidate the pathogenesis of Parkinson's disease, but only focus on neurons pathophysiology change. The iPSC differentiated enterocytes-neuron co-culture system has not been established. we will create iPSC gut mucosa, neurons, and immune cells co-culture system to clarify the mechanism of synucleinopathy.

Research summary

Present specialized field
Pharmacology

Present specialized field

Pharmacology

Papers
1.	2021/05	Evaluation of the Effects of Solvents Used in the Fabrication of Microfluidic Devices on Cell Cultures. │ Micromachines │ 12 (5) (Co-authored)
2.	2019/02	NOX1/NADPH oxidase regulates the expression of multidrug resistance-associated protein 1 and maintains intracellular glutathione levels. │ The FEBS journal │ 286 (4),pp.678-687 (Co-authored)

Papers

2021/05

2019/02

E-Mail Address