Ritsumeikan University Researcher Database
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(Last updated : 2024-11-05 12:46:35)
WEN XIAOPENG
Department / Course
College of Pharmaceutical Sciences Department of Pharmaceutical Sciences
Title / Position
Assistant Professor
Achievement
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Profile
Academic background
Business career
Committee and society
Research activities
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Subject of research
Research summary
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Present specialized field
research
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Other research achievements
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Winning science prize
Grants-in-Aid for Scientific Research -KAKENHI-
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teaching
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researchmap Researcher code
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Academic background
1.
2015/04~2019/03
Doctorial Course │ Integrated Medical Science │ Graduate School, Division of Medicine │ Kyoto Prefectural University of Medicine │ Completed Doctor of Philosophy
2.
2013/04~2015/03
Master Course │ Medical Science │ Graduate School, Division of Medicine │ Kyoto Prefectural University of Medicine │ Completed Master of Medical Science
3.
2007/09~2011/07
Faculty of Pharmaceutical Science │ Guangdong Pharmaceutical University │ Graduated Bachelor of Pharmacy
Business career
1.
2021/05/20 ~
Visiting Assistant Professor │ Kamei Group │ Kyoto University iCeMS Institute for Integrated Cell-Material Sciences
2.
2021/04 ~
Assistant Professor │ College of Pharmaceutical Sciences │ Ritsumeikan University
3.
2019/04 ~ 2021/03
Research Assistants │ The Kamei Group │ Institute for Integrated Cell-Material Sciences
Research activities
1.
2019/04 ~
The Japanese Pharmacological Society
Subject of research
1.
Synucleinopathies and enteric nerves
Research summary
Development of an enterocytes-neuron co-culture system and synucleinopathy mechanism clarification
Synucleinopathy, such as Parkinson's disease and dementia with Lewy bodies, are neurodegenerative diseases in various factors, such as inflammation and oxidative stress, cause aggregation of alpha-synuclein in neurons, leading to neuronal cell death. Aggregation of α-synuclein in nerves is associated with intestinal microbes and inflammation of the gut, and the onset of Parkinson's disease is presumed to be from gut. Clarify the pathology of synucleinopathy in the gut mucosa and its nerves, leading to develop the prevention and early treatment of synucleinopathy. The application of induced pluripotent stem cells (iPSC) has been widely used to elucidate the pathogenesis of Parkinson's disease, but only focus on neurons pathophysiology change. The iPSC differentiated enterocytes-neuron co-culture system has not been established. we will create iPSC gut mucosa, neurons, and immune cells co-culture system to clarify the mechanism of synucleinopathy.
Present specialized field
Pharmacology
Papers
1.
2021/05
Evaluation of the Effects of Solvents Used in the Fabrication of Microfluidic Devices on Cell Cultures. │ Micromachines │ 12 (5) (Co-authored)
2.
2019/02
NOX1/NADPH oxidase regulates the expression of multidrug resistance-associated protein 1 and maintains intracellular glutathione levels. │ The FEBS journal │ 286 (4),pp.678-687 (Co-authored)
E-Mail Address