Researcher Database

（Last updated : 2025-02-20 14:15:12）　

NEGORO RYOSUKE

Department / Course College of Pharmaceutical Sciences Department of Pharmacy

Title / Position Assistant Professor

Click to view the Scopus page. The data was downloaded from Scopus API on Mar 10, 2025. via http://api.elsevier.com and http://www.scopus.com .

Academic background
1.	2015/04～2019/03	Doctorial Course │ Graduate School of Pharmaceutical Sciences │ Osaka University │ Completed Doctor of Pharmacy
2.	2009/04～2015/03	Faculty of Pharmaceutical Sciences │ Setsunan University. │ Graduated

Business career
1.	2019/04/01 ～ 2024/03/31	│ Laboratory of Molecular Pharmacokinetics, Collegeof Pharmaceutical Sciences , │ Ritsumeikan University

Subject of research
1.	Prediction of intestinal drug absorption and intestinal drug metabolism

Research summary
Model construction of drug intestinal absorption and drug intestinal first-pass metabolism Administered drug are absorbed and metabolized in the small intestine. A model that could evaluate drug absorption and metabolism in the small intestine would be useful for pharmacokinetic study. Currently, experimental animals and cancer cell lines such as Caco-2 cells are widely used as intestinal models because primary human small intestinal epithelial cells are difficult to obtain and culture. However, these existing models do not accurately reflect the human small intestine functions. Recently, Molecular biology research methods such as genome editing technology and gene expression control technology using viral vectors are rapidly developing. In this study, we will work on constructing models that could predict drug intestinal absorption and drug metabolism using by molecular biological technologies such as genome editing technology and viral vectors.

Present specialized field
Biological pharmacy, Medical pharmacy, General anatomy (including histology/embryology) (Keyword：Intestinal drug absorption, Intestinal drug metabolism, drug transporter, drug-metabolizing enzyme, iPS cells)

Works
1.	2023/10/20	Generation of highly functional intestinal epithelial cell and hepatocyte models applicable to pharmacokinetic studies using genome editing technology

Subject
1.	英語JP1