Researcher Database

（Last updated : 2023-06-07 10:57:23）　

UEHARA RYO

Department / Course College of Life Sciences Department of Biotechnology

Title / Position Assistant Professor

Academic background
1.	～2010/03	Doctoral Program (1st Semester) │ Division of Advanced Science and Biotechnology │ Graduate School of Engineering │ Osaka University │ Completed
2.	～2013/03	Doctoral Program (2nd Semester) │ Division of Advanced Science of Biotechnology │ Graduate School of Engineering │ Osaka University │ Completed Ph.D.
3.	～2008/03	Division of Applied Science │ School of Engineering │ Osaka University │ Graduated

Business career
1.	2019/04/01 ～ 2020/03/31	Assistant Professor │ │ Ritsumeikan University R-GIRO
2.	2019/02/01 ～ 2019/03/31	Senior Researcher │ │ Ritsumeikan University R-GIRO
3.	2013/10/01 ～ 2019/01/24	Visiting Fellow │ │ National Institutes of Health
4.	2013/04/01 ～ 2013/09/30	Appointed Researcher │ │ Osaka University

Research activities
1.		Protein Science Society of Japan

Subject of research
1.	Molecular biology of RNA/DNA hybrid
2.	Protein engineering of hyperthermophilic protease and its application

Present specialized field
Molecular biology, Structural biochemistry, Cell biology (Keyword：Genome integrity, RNase H, R-loop, DNA repair, Subtilisin)

Books
1.	2016	Biotechnology of Microbial Enzymes: Production, Biocatalysis and Industrial applications │ ,pp.81-117
2.	2012	Serine Proteases: Mechanism, Structure and Evolution │ ,pp.1-32

Papers
1.	2022/04	Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function. │ Scientific reports │ 12 (1),pp.6674
2.	2022/04	MEK/ERK-mediated oncogenic signals promote secretion of extracellular vesicles by controlling lysosome function. │ Cancer science │ 113 (4),pp.1264-1276
3.	2021/02	Insertion loop-mediated folding propagation governs efficient maturation of hyperthermophilic Tk-subtilisin at high temperatures. │ FEBS letters │ 595 (4),pp.452-461
4.	2020/09	Crystal structure of a GH1 β-glucosidase from Hamamotoa singularis. │ Protein science : a publication of the Protein Society │ 29 (9),pp.2000-2008
5.	2020/02	Crystal structures of the cell-division protein FtsZ from Klebsiella pneumoniae and Escherichia coli. │ Acta crystallographica. Section F, Structural biology communications │ 76 (Pt 2),pp.86-93
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Grants-in-Aid for Scientific Research -KAKENHI-
1.	2019/08/30 ～ 2021/03/31	Structural basis for DNA repair machinery including RNA/DNA heteroduplex │ Grant-in-Aid for Research Activity start-up