Researcher Database

（Last updated : 2025-08-28 13:06:19）　

SUGANO KIYOHIKO

Department / Course College of Pharmaceutical Sciences Department of Pharmacy

Title / Position Professor

Other Affiliations
1.	Graduate School of Pharmacy

Academic background
1.	2002/08 Degree Acquisition	│ Toho university Ph.D.
2.	～1993/03	Department of chemistry │ Faculty of Science and Engineering │ Waseda University │ Graduated
3.	～1995/03	Chemistry │ Faculty of Science and Engineering │ Waseda University │ Completed

Business career
1.	2014/01 ～ 2017/03	│ │ Toho university

Research activities
1.		American association of pharmaceutical sciences
2.		The Academy of Pharmaceutical Science and Technology, Japan (APSTJ)
3.		The Japanese Society for the Study of Xenobiotics

Subject of research
1.	Physicochemical profiles of active pharmaceutical ingredient and excipient
2.	Physics and chemistry of oral drug absorption

Research summary
Physics and chemistry of oral drug absorption Physicochemical profiles of active pharmaceutical ingredient and excipient The oral bioavailability (BA) of a drug is one of the key success factors for drug discovery and development. Computational BA prediction is anticipated to be a powerful tool to enable developing a high quality drug product and optimizing the therapeutic value. However, it still remains a big challenge to achieve accurate BA prediction. BA is determined by complex interactions between the physicochemical properties of a drug and the physiological conditions of the gastrointestinal (GI) tract. The GI environment changes dynamically with a concomitant intake of food and other drugs. Our research goal is to provide a scientific basis for BA prediction. We are experimentally investigating the physicochemical interactions between a drug and biological GI components at the molecular level. Mathematical models to describe the interactions are also investigated. We actively collaborate with pharmaceutical companies to achieve our research goal and implement the achievements in drug discovery and development.

Present specialized field
Physical pharmacy (Keyword：Biopharmaceutics, Physical pharmacy, Physical chemistry, Drug discovery, Drug development)

Books
1.	2012/08/20	Biopharmaceutics Modeling and Simulations: Theory, Practice, Methods, and Applications

Papers
1.	2025/01	Dissolution profiles of high-dose salt-form drugs in bicarbonate buffer and phosphate buffer. │ Journal of pharmaceutical sciences │ 114 (1),pp.477-485
2.	2024/07	A commentary on "Are all measures of liver Kpuu a function of FH, as determined following oral dosing, or have we made a critical error in defining hepatic drug clearance?". │ European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences │ 198,pp.106799
3.	2024/06	Drug Crystal Precipitation in Biorelevant Bicarbonate Buffer: A Well-Controlled Comparative Study with Phosphate Buffer. │ Molecular pharmaceutics │ 21 (6),pp.2854-2864
4.	2024/05	Dissolution Profiles of Immediate Release Products of Various Drugs in Biorelevant Bicarbonate Buffer: Comparison with Compendial Phosphate Buffer. │ Pharmaceutical research │ 41 (5),pp.959-966
5.	2024/01	Bicarbonate buffer dissolution test with gentle mechanistic stress for bioequivalence prediction of enteric-coated pellet formulations. │ European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences │ 192,pp.106622
Display All（62）