Researcher Database

（Last updated : 2023-06-05 08:22:35）

HASHIMOTO Takeshi

Department / Course College of Sport and Health Science Department of Sport and Health Science

Title / Position Professor

Other Affiliations
1.	Graduate School of Sport and Health Science
2.	Research Organization of Science and Technology The Bio Medical Engineering Research Center
3.	Research Organization of Science and Technology Institute of Advanced Research for Sport and Health Science

Academic background
1.	2004/03 Degree Acquisition	│ Kyoto University Ph.D. (Human and Environmental Studies)
2.	2001/03 Degree Acquisition	Master
3.	～1999/03	Department of Natural Environmental Studies │ Faculty of Integrated Human Studies │ Kyoto University │ Graduated
4.	～2001/03	Master Course │ Graduate School, Division of Human and Environmental Studies │ Kyoto University │ Completed
5.	～2004/03	Doctoral Program (2nd Semester) │ Graduate School, Division of Human and Environmental Studies │ Kyoto University │ Completed

Business career
1.	2017/04/01	Professor │ Faculty of Sport and Health Science, │ Ritsumeikan University

Research activities
1.		American College of Sports Medicine
2.		American Society for Experimental Organism and Medical Science
3.		Japan Society of Exercise and Sports Physiology
4.		The Japanese Biochemical Society
5.		Japan Society of Physical Fitness and Sports Medicine
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Subject of research
1.	Effects of exercise and nutrition against sarcopenic obesity
2.	Effects of exercise and nutrition on cognitive improvement
3.	Effects of exercise and nutrition on health promotion
4.	Molecular mechanisms of lipolysis in adipocytes
5.	The effect of exercise training on the lipolytic activity in adipocytes

Research summary
Elucidation of molecular mechanism of exercise effect on energy metabolism of the whole body The mitochondria are important organelles associated with various diseases such as apoptosis, aging, Parkinson's disease, Alzheimer's disease, cancer. While deterioration of physical function due to metabolic syndrome and aging is problematic today, the demand for exercise prescription aimed to activate mitochondria, which is the key to energy metabolism, seems to rise more and more in the future. If the molecular mechanism of exercise effect becomes clear, it is expected to construct more effective exercise prescription. According to my research so far, it has been suggested that lactic acid produced by exercise may contribute to the increase of mitochondrial biogenesis and the construction of antioxidant system through active oxygen in the skeletal muscle. Lactic acid is expected to be able to make a new and great contribution to overcome the major problems of our times such as lifestyle diseases and aging. Then, I am engaged in the research majorly to understand the molecular mechanism by which lactic acid improves the functions of mitochondoria through interaction with many factors. Therefore, I attempt to clarify the functional correlation between lactic acid and mitochondorion through the basic research using primary cultured cells from cultured muscle cells and disease model animals at a cell level and the research at an individual level using animals. On the other hand, it is important in homeostasis of systemic lipid metabolism that adipose is decomposed in adipose tissue and "adipose mobilization" is properly performed by which fatty acid is utilized in muscle tissue. The failure of the lipid metabolism control mechanism is a factor of metabolic syndrome. There are many unclear points about the lipolysis control mechanism which is an initial phase of the adipose mobilization. Therefore, I am currently working on the elucidation of its molecular mechanism. In addition, focusing on what kind of change is occurring in the adipose mobilization mechanism for the metabolic syndrome and what kind of exercise can overcome it, I am advancing the research at a cell level or at an individual level using disease model animals.

Present specialized field
Sports Science, Nutritional science and health science, Physiology, Metabolism and endocrinology, Cognitive and brain science, Cell biology, Applied molecular and cellular biology, Food sciences, Biomedical engineering (Keyword：Energy metabolism, lactate, cognitive function, mitochondria, skeletal muscle, heart, adipocyte, lipolysis, anti-aging, biochemistry, lipid droplet, glucose metabolism, lipid metabolism, transporter, metabolic syndrome, obesity, hypoxia)

Books
1.	2021/11/06	Science and Development of Muscle Hypertrophy │ (Co-authored)

Papers
1.	2023/05/15	Attenuated Pulsatile Transition to the Cerebral Vasculature during High-intensity Interval Exercise in Young Healthy Men │ Experimental Physiology │ (Co-authored)
2.	2023/05/12	Ergogenic Effects of Very Low to Moderate Doses of Caffeine on Vertical Jump Performance │ International Journal of Sport Nutrition and Exercise Metabolism │ (Co-authored)
3.	2022/12/27	Executive function during exercise is diminished by prolonged cognitive effort in men │ Scientific Reports │ 12 (22408) (Co-authored)
4.	2022/09/24	Acute effect of caffeine supplementation on 100-m sprint running performance: A field test │ Medicine & Science in Sports & Exercise │ 55 (3),pp.525-533 (Co-authored)
5.	2022/07/06	Effects of Quercetin Glycoside Supplementation Combined With Low-Intensity Resistance Training on Muscle Quantity and Stiffness: A Randomized, Controlled Trial │ Frontiers in Nutrition │ 9,pp.912217 (Co-authored)
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Academic conference presentation
1.	2020/10/30	Cerebral metabolism and executive function following exercise (European College of Sport Science)
2.	2019/09/18	Sustainable aerobic exercise mode to improve executive function (The 1st International Sport Neuroscience Conference 2019)
3.	2019/09/18	Sustainable resistance exercise mode to improve cognitive function (The 1st International Sport Neuroscience Conference 2019)
4.	2019/07/09	The importance of breakfast glycemic control on systemic BDNF and dynamic cerebral autoregulation in men. (Physiology 2019)
5.	2019/07/06	Catechin-rich green tea intake reduces exercise-induced blood pressure elevation and enhances executive function (24th annual congress of the European College of Sport Science)
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Winning science prize
1.	2014/05	American College of Sport Medicine ACSM Fellow
2.	2006/07	JSPS Postdoctoral Fellowships for research abroad

Grants-in-Aid for Scientific Research -KAKENHI-
1.	2019/06 ～ 2022/03	Identification of blood biomarkers reflecting qualitative changes in skeletal muscle │ Challenging Research (Exploratory)
2.	2018/04 ～ 2021/03	Paradox of effect of exercise on cognitive function and cardiovascular system │ Grant-in-Aid for Scientific Research (B)
3.	2017/04 ～ 2020/03	Development of exercise and diet therapies for the improvement of risk of cardiovascular disease targeting novel myokine │ Grant-in-Aid for Scientific Research (B)
4.	2016/04 ～ 2019/03	Identification of local sites of adipokine production involved in the reduction of cardiovascular disease risk by exercise training │ Grant-in-Aid for Challenging Exploratory Research
5.	2015/04 ～ 2018/03	New mechanism of mitochondrial biogenesis mediated by nutritional substrate in skeletal muscle │ Grant-in-Aid for Challenging Exploratory Research
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