Researcher Database

（Last updated : 2022-11-04 18:52:03）

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FUJITA Takuya

Department / Course College of Pharmaceutical Sciences Department of Pharmacy

Title / Position Professor

Other Affiliations
1.	Research Organization of Open Innovation & Collaboration Research Center for Medical and Long-Term Care Management
2.	Research Organization of Science and Technology The Bio Medical Engineering Research Center
3.	Research Organization of Science and Technology Research Center for Drug Discovery and Development Scieces
4.	Graduate School of Pharmacy

Academic background
1.	～1990/03	Doctoral Program (1st Semester) │ Division of Pharmacy │ Graduate School, Division of Pharmaceutical Sciences │ Kyoto University │ Completed
2.	～1992/02	Doctorial Course │ Division of Pharmacy │ Graduate School, Division of Pharmaceutical Sciences │ Kyoto University │ Unfinished
3.	1996/05 Degree Acquisition	│ Kyoto University Ph.D.
4.	～1988/03	Division of Pharmacy │ Faculty of Pharmaceutical Science │ Kyoto University │ Graduated

Business career
1.	1992/03/01	Research Associate │ │ Kyoto Pharmaceutical University
2.	1996/09/01 ～ 1997/09/20	PostDoctor │ │ Medical College of Georgia
3.	1998/04/01	Assistant Professor │ │ Kyoto Pharmaceutical University
4.	2000/04/01 ～ 2007/03/31	Associate Professor │ │ Kyoto Pharmaceutical University
5.	2000/07/10 ～ 2000/09/09	Invited Researcher │ │ Medical College of Georgia
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Research activities
1.		The Pharmaceutical Society of Japan
2.		The Academy of Pharmaceutical Science and Technology, Japan
3.		The Japanese Society for the Study of Xenobiotics
4.		Japanese Society of Pharmaceutical Health Care and Sciences
5.		American Association of Pharmaceutical Scientists

Subject of research
1.	(1) Study on Prediction of Intestinal Absorption of Medicine Candidate Compounds
2.	(2) Functional Analysis of Organic Ion Transporter Group Emerging in Central Nervous System
3.	(3) Functional Linkage of Receptor/Channel and Transporter in Central Nervous System

Research summary
A biopharmaceutical research on organic ion transporter that functions as a central nervous system adjustment factor and a research on the evaluation of the gastrointestinal absorption property of medicament candidate compounds [Research Subject (1) Outline] My main research subject is to analyze a variety of the organic transporter's functions which express on these cells using primary culture system of neuron or astrocyte. [Research Subject (2) Outline] I advance the research on the possibilities that the transporter is concerned as an adjustment factor that expresses in the central nervous system. [Research Subject (3) Outline] I identify the transporter related with the absorption of the medicament candidate compounds and perform an quantative prediction of the contribution of discharging transporters to the absorption.

Present specialized field
Medical pharmacy, Applied Pharmacology, Neurochemistry/ Neuropharmacology (Keyword：Estimation of intestinal drug absorption, Membrane transport, Transporter, Pharmacokinetics, Neurochemistry, Drug Delivery SYstem (DDS))

Papers
1.	2022/11	Inhibition of Liquid–Liquid Phase Separation for Breaking the Solubility Barrier of Amorphous Solid Dispersions to Improve Oral Absorption of Naftopidil. │ Pharmaceutics │ 14 (12),pp.2664 (Co-authored)
2.	2022/08	Alleviative effects of glutamate against chemotherapeutics agent-induced intestinal mucositis. │ Journal of Physiology and Pharmacology │ 73 (4),pp.539-546 (Co-authored)
3.	2022/07/01	Mesenchymal stem cells promote IL-6 secretion and suppress the gene expression of proinflammatory cytokines in contractile C2C12 myotubes │ Biological and Pharmaceutical Bulletin │ 45 (7),pp.962-967 (Co-authored)
4.	2022/05/18	Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System. │ Cells │ 11 (10),pp.1677 (Co-authored)
5.	2022/02/15	Prediction of oral drug absorption in rats from in vitro data. │ Pharmaceutical Research │ ,pp.in press (Co-authored)
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Academic conference presentation
1.	2019/11/04	Transport Characteristics of Amino Acids-Conjugated 5-aminosalicylic Acid Derivatives via H⁺-Coupled Oligopeptide Transporter 1. (2019 AAPS Pharm Sci 360)
2.	2016/11/14	Enhanced Cellular Uptake and Retention of 5-Aminosalicylic Acid by Magnetic Liposomes. (Association of American Pharamceutical Sciences Annual Meeting and Exposition 2016)
3.	2015/10/27	Assessment of Intestinal Absorption of New Chemical Entities: In Vitro/In Vivo Correlation. (Association of American Pharamceutical Sciences Annual Meeting and Exposition 2015)
4.	2015/10/25	Effects of surface charge and PEG modification of liposomes on their uptake in Caco-2 cells across unstirred water layer. (Association of American Pharamceutical Sciences Annual Meeting and Exposition 2015)
5.	2011/11/18	Innovative strategies for drug development using microdosing clinical studies (NEDO Microdosing PJ) 2011 (6): Prediction of D2 receptor occupancy in the human brain by the receptor antagonists. (26th JSSX annuak meeting)
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External Researcher ID
ORCID ID
https://orcid.org/0000-0002-7724-6522
Researcher ID
AAC-3442-2022