Researcher Database

（Last updated : 2023-03-08 15:36:33）

ICHIKAWA Nobuhiro

Department / Course College of Pharmaceutical Sciences Department of Pharmacy

Title / Position Professor

Other Affiliations
1.	Graduate School of Pharmacy
2.	Research Organization of Open Innovation & Collaboration Research Center for Medical and Long-Term Care Management

Academic background
1.	1995/03 Degree Acquisition	│ Kyushu University Ph.D. (Pharmaceutical Sciences)
2.	～1984/03	Master Course │ Department of Pharmaceutical Science │ School of Pharmaceutical Sciences │ Nagasaki University │ Completed

Research activities
1.		The Pharmaceutical Society of Japan
2.		Japanese Society of Pharmaceutical Health Care and Sciences
3.		The Japanese Society of Clinical Pharmacology and Therapeutics
4.		The Japanese Society for the Study of Xenobiotics
5.		The Academy of Pharmaceutical Science and Technology, Japan
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Subject of research
1.	Proper Use of Medicinal Products
2.	Optimization of Medical Treatment

Research summary
A research on drug migration to central nervous system, a research on the proper use of medicament and the optimization of pharmacotherapy, and a research on the emissions of PPCPs to the environment 1) A research on the proper use of chemotherapeutics and the optimization of pharmacotherapy ① Elucidation of the drug resistance mechanism of carcinostatic agent ・A research on chemotherapy resistance factors in cerebral tumor ・The effect of overcoming multiple drug resistance using carcinostatic agent resistance cells ③Investigation of the method for reducing adverse effect of antimicrobe agent and the proper dosage ・An investigation of the antimicrobial susceptibility of drug resistance of lactobacillus preparation and butyric acid bacteria preparation 2) A research on promotion of the proper use of medicament ① Comparison the quality and drug effect between the Chinese herbal medicine extract products for medical use ② An evaluation of the ecological effect of PPCPs (pharmaceuticals and personal care products) in the environment ③ An investigation of the ecological effect of medicament using nematodes ④ A research on the proper use of generic drugs ⑤ A research on the development of the environment to promote self‐medication

Present specialized field
Medical pharmacy, Biological System Pharmaceutical Science (Keyword：Clinical Pharmacy, Clinical Pharmacology, Drug Informatics)

Papers
1.	2023/01/13	Development of a useful single‑reference HPLC method for therapeutic drug monitoring of phenytoin and carbamazepine in human plasma │ Analytical Sciences │ 39,pp.01-08 (Co-authored)
2.	2022/12	Caffeine Content of Beverages. │ J. Food Sci. (kyoto Women's Univ.) │ ,pp.01-08 (Co-authored)
3.	2022/09	The effects on growth and reproductive function by parabens in C. elegans. │ Fundam. Toxicol. Sci. │ 9 (5),pp.145-150 (Co-authored)
4.	2022/08	Effects of chronic exposure of Caenorhabditis elegans to neonicotinoids (imidacloprid, dinotefuran) over multiple generations. │ Japanese Journal of Food Chemistry and Safety │ 29 (2),pp.1-8 (Co-authored)
5.	2022/07	Multigenerational effects of neonicotinoids (acetamiprid, clothianidin) on growth, fertility and motility of nematode C. elegans. │ Fundam. Toxicol. Sci. │ 9 (3),pp.95-102 (Co-authored)
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Academic conference presentation
1.	2001/09	Expression of metallothionein-IA, IIA and III mRNA in human brain tumor cells and effect of anticancer agents on theses levels (61st International Congress of F.I.P.)
2.	2002/09	Evaluation for corneal epithelial disorders of eyedrops by electrophysiological method (62nd International Congress of F.I.P.)
3.	2003/05	Electrophysiological study for estimation of corneal epithelial disorders after instillation of antiglaucomatous eyedrops. (The 2nd World Congress of the Board of Pharmaceutical Sciences of FIP)
4.	2003/09	Effect of blood components on gene delivery with polyethylenimine in the cultured endothelial cells. (63rd International Congress of F.I.P.)
5.	2004/09	Effect of blood components on gene delivery with polyethylenimine in the cultured endothelial cells. (64th International Congress of F.I.P.)
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Winning science prize
1.	2012/10	Pfizer Highly Cited Paper Award (Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes). The Journal of Toxicological Sciences, 34(2) 227-232 (2009))