Researcher Database

（Last updated : 2024-03-22 16:35:12）

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TAKAHASHI Takuya

Department / Course College of Life Sciences Department of Bioinformatics

Title / Position Professor

Other Affiliations
1.	Graduate School of Life Sciences

Academic background
1.	1991/03 Degree Acquisition	│ The University of Tokyo Ph.D. in Science (The University of Tokyo)
2.	～1985	Department of Physics │ Faculty of Science │ The University of Tokyo │ Graduated
3.	～1991/03	Doctorial Course │ Graduate School, Division of Science │ The University of Tokyo │ Completed

Business career
1.	2010/04/01	Professor │ College of Life Sciences │ Ritsumeikan University
2.	2008/04/01 ～ 2010/03/31	Associate Professor │ College of Life Sciences │ Ritsumeikan University
3.	2003/04/01 ～ 2008/03/31	Associate Professor │ Graduate School of Scienceand Engineering │ Ritsumeikan University
4.	1997/09/01 ～ 2003/03/31	│ │ nins

Committee and society
1.	2014/01 ～ 2016/01	Japan Society for the Promotion of Science Grants-in-Aid forScientific Research

Research activities
1.		The Biophysical Society of Japan
2.		Protein Science Society of Japan

Research summary
Connecting Life Structure Information to Functional Information Based on enormous amount of observation data including DNA array and protein cubic structure, I will clarify the mechanisms of biometric structure formation and life function appearance, mainly using the approach in terms of theoretical calculation.

Present specialized field
Structural Biochemistry, Biophysics (Keyword：Structural biology, biophysics, molecular science, computer science)

Books
1.	2012/04	Practical Estimation of TCR-pMHC Binding Free-Energy Based on the Dielectric Model and the Coarse-Grained Model │ ,pp.107-134 (Co-authored)

Papers
1.	2023/04/11	Molecular Mechanisms of Functional Modulation of Transcriptional Coactivator PC4 via Phosphorylation on Its Intrinsically Disordered Region │ ACS OMEGA │ 8 (16),pp.14572-14582 (Co-authored)
2.	2023/04/06	Carbon nanotube recognition by human Siglec-14 provokes inflammation │ nature nanotechnology │ 18,pp.628-636 (Co-authored)
3.	2022/03/21	Sphingolipids with 2-hydroxy fatty acids aid in plasma membrane nanodomain organization and oxidative burst │ (Co-authored)
4.	2022/02/08	Information quantity for secondary structure propensities of protein subsequences in the Protein Data Bank │ Biophysics and Physicobiology │ 19 (Co-authored)
5.	2021/05/04	All-Atom Molecular Dynamics Elucidating Molecular Mechanisms of Single-Transmembrane Model Peptide Dimerization in a Lipid Bilayer │ ACS Omega │ 6 (17),pp.11458-11465 (Co-authored)
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Academic conference presentation
1.	2023/11/14	Elucidation of hydration dynamics around peptides and proteins by molecular dynamics simulation (The 61th annual meeting of biophysical society of japan)
2.	2023/06/11	Molecular dynamics study of hydration dynamics around peptides with di#erent helix propensities (The 23rd Annual Meeting of the Protein Science Society of Japan)
3.	2023/03	Development of drug discovery platform technology based on the VcMD method　-Evaluation of SARS CoV-2 PLpro candidate inhibitors- (The 143rd Annual Meeting of the Pharmaceutical Society of Japan (Sapporo))
4.	2022/09	A Coarse-Grained Molecular Dynamics Study of the Effect of Charged Residues of Proteins on Liquid-Liquid Phase Separation (The 60th annual meeting of biophysical society of japan)
5.	2022/09	Elucidation of hydration dynamics around chignolin and mutants using molecular dynamics (The 60th annual meeting of biophysical society of japan)
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Message
1.	Linking biological structure information with functional information: Elucidation of formation of three-dimensional structure of biomolecules, and elucidation of how functions are expressed from three-dimensional structure information. Living organisms are composed of tissues, cells, intracellular organelles, etc. Biological phenomena are realized through various functions of enormous biopolymers constituting these living tissues. Specifically, enzymes in solution in the living body have a function to control complex biological reactions through a specific three-dimensional structure, and ion channels in the biological membrane control transmission and accumulation of various ions , Involved in information processing and intracellular signaling in the brain, basic information for determining its three-dimensional structure is stored in DNA. With the recent progress in analysis technology of DNA sequence information and protein three-dimensional structure information, enormous amounts of primary structure data and tertiary structure data have been clarified, and the rapid development of bioinformatics is expected there. In my laboratory, in order to elucidate the formation of a three-dimensional structure from this primary structure information and to clarify how the function is expressed from the three-dimensional structure information, a method such as simulation or energy calculation Use it to study. Various methods such as informatical methods such as construction of physicochemical theory based on experimental data, database analysis etc., various molecular simulation, quantum chemical calculation, approximate calculation using continuum model are used.

Home Page
http://www.ritsumei.ac.jp/~tkhs/index_e.html