研究者学術情報データベース

コトク　ナオユキ
古徳　直之
KOTOKU NAOYUKI

所属薬学部薬学科

職名教授

論文
1.	2024/08/27	Concise and Stereospecific Total Synthesis of Arenastatin A and Its Segment B Analogs │ Molecules │ 29 (17),4058 (共著)
2.	2024/03/20	Unified Synthesis and Biological Evaluation of Makaluvamine J and Its Analogs │ Molecules │ 29 (6),1389 (共著)
3.	2023/05/19	Oxidative Cyclization at ortho-Position of Phenol: Improved Total Synthesis of 3-(Phenethylamino)demethyl(oxy)aaptamine │ Marine Drugs │ 21 (5),311 (共著)
4.	2022/12/08	Anti-Mycobacterial N-(2-Arylethyl)quinolin-3-amines Inspired by Marine Sponge-Derived Alkaloid. │ Molecules │ 27 (24),8701 (共著)
5.	2022/07/12	Possible Therapeutic Utility of anti-Cell Adhesion Molecule 1 Antibodies for Malignant Pleural Mesothelioma. │ Front. Cell Dev. Biol. │ 10,945007 (共著)
6.	2022/01/24	Study of the Structure–Activity Relationship of an Anti-Dormant Mycobacterial Substance 3-(Phenethylamino)Demethyl(oxy)aaptamine to Create a Probe Molecule for Detecting Its Target Protein │ Marine Drugs │ 20 (2),98 (共著)
7.	2021/03/15	Fasciospyrinadinone and Fasciospyrinadinol, Novel 3-Alkylpyridine Sesquiterpenoids from An Indonesian Marine Sponge, as Selective Growth Inhibitors of the Cancer Cells under Nutrient Starvation. │ Heterocycles │ 103 (2),827-838頁 (共著)
8.	2020/05	3-(Phenethylamino)demethyl(oxy)aaptamine as an anti-dormant mycobacterial substance: Isolation, evaluation and total synthesis. │ Tetrahedron Letters │ 61 (22),151924 (共著)
9.	2020/03	Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain. │ JCI Insight │ 5,e133348 (共著)
10.	2019/03	Structure-Activity Relationship of Biakamide, Selective Growth Inhibitors under Nutrient-starved Condition from Marine Sponge │ Chemical & Pharmaceutical Bulletin │ 67 (3),210-223 (共著)
11.	2019/03	Target Identification of the Marine Natural Products Dictyoceratin-A and -C as Selective Growth Inhibitors in Cancer Cells Adapted to Hypoxic Environments │ Marine Drugs │ 17 (3),163 (共著)
12.	2017/03	Short-step Synthesis and Structure-activity Relationship of Cortistatin A Analogs. │ Tetrahedron │ 73 (10),1342-1349 (共著)
13.	2017/02	Biakamides A - D, Unique Polyketides from a Marine Sponge, Act as Selective Growth Inhibitors of Tumor Cells Adapted to Nutrient Starvation. │ The Journal of Organic Chemistry │ 82 (3),1705-1718 (共著)
14.	2017/01	Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II. │ J. Nat. Med. │ 71 (1),44-49 (共著)
15.	2016/07	N-Methylniphatyne A, a new 3-alkylpyridine alkaloid as an inhibitor of the cancer cells adapted to nutrient starvation, from an Indonesian marine sponge of Xestospongia sp. │ Chem. Pharm. Bull. │ 64 (7),766-771 (共著)
16.	2016/02	Search for Anti-angiogenic Substances from Natural Sources │ Chem. Pharm. Bull. │ 64 (2),128-134 (共著)
17.	2016/01	Furospinosulin-1, marine spongean furanosesterterpene, suppresses the growth of hypoxia-adapted cancer cells by binding to transcriptional regulators p54nrb and LEDGF/p75. │ ChemBioChem │ 17 (2),181-189 (共著)
18.	2015/12	Structure-activity relationship and in vivo anti-tumor evaluation of dictyoceratin-A and -C, hypoxia-selective growth inhibitors from marine sponge │ Marine Drugs │ 13 (12),7419-7432 (共著)
19.	2015/05	Identification and functional analysis of 2-hydroxyflavanone C-glucosyltransferase in soybean (Glycine max). │ FEBS Letters │ 589 (15),1778-1786 (共著)
20.	2015/04	Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp. │ Bioorg. Med. Chem. │ 23 (13),3534-3541 (共著)
21.	2015/03	Enantioselective synthesis of dictyoceratin-A (smenospondiol) and -C, hypoxia-selective growth inhibitors from marine sponge │ Bioorg. Med. Chem. │ 23 (5),966-975 (共著)
22.	2014/08	Xylarianaphthol-1, a novel dinaphthofuran derivative, activates p21 promoter in a p53-independent manner │ Bioorganic & Medicinal Chemistry Letters │ 24 (15),3389-3391 (共著)
23.	2014/04	Synthesis and evaluation of effective photoaffinity probe molecule of furospinosulin-1, a hypoxia-selective growth inhibitor │ Bioorg. Med. Chem. │ 22 (7),2102-2112 (共著)
24.	2013/10	Synthetic Studies of Cortistatin A Analogue from the CD-Ring Fragment of Vitamin D2 │ Chemical & Pharmaceutical Bulletin │ 61 (10),1024-1029 (共著)
25.	2012/10	Asymmetric Total Synthesis of (-)-Stenine and 9a-epi-Stenine │ Chemistry - A European Journal │ 18 (43),13861-13870 (共著)
26.	2012/08	Creation of Readily Accessible and Orally Active Analogue of Cortistatin A │ ACS Medicinal Chemistry Letters │ 3 (8),673-677 (共著)
27.	2011/09	Concise synthesis and structureeactivity relationship of furospinosulin-1, a hypoxia-selective growth inhibitor from marine sponge │ Tetrahedron │ 67,6673-6678 (共著)
28.	2011/07	Stereoselective Synthesis of Core Structure of Cortistatin A │ Organic Letters │ 13 (13),3514-3517 (共著)
29.	2011/06	Synthetic Study of Carbocyclic Core of Cortistatin A, an Anti-Angiogenic Steroidal Alkaloid from Marine Sponge │ Heterocycles │ 83 (7),1535-1552 (共著)
30.	2011/01	Anti-angiogenic effect of triterpenoidal saponins from Polygala senega. │ J. Nat. Med. │ 65 (1),149-156 (共著)
31.	2010/07	Probe molecule equipped with boronic acid moiety as a reversiblecross-linking group improves its binding affinity │ Bioorg. Med. Chem. Lett. │ 20 (14),4152-4155 (共著)
32.	2010/06	Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria │ Bioorg. Med. Chem. Lett. │ 20 (12),3658-3663 (共著)
33.	2008/11	Synthesis of CD-ring Structure of Cortistatin A, an Anti-angiogenic Steroidal Alkaloid from Marine Sponge │ Tetrahedron Letters │ 49 (49),7078-7081 (共著)
34.	2008/09	Structure-activity Relationship (SAR) Study of Bastadin 6, an Anti-angiogenic Brominated-tyrosine Derived Metabolite from Marine Sponge. │ Archiv der Pharmazie │ 341,568-577 (共著)
35.	2008/06	Synthesis of BC-ring model of globostellatic acid X methyl ester, an anti-angiogenic substance from marine sponge │ Bioorganic & Medicinal Chemistry Letters │ 18 (12),3532-3535 (共著)
36.	2007/09	Concise asymmetric total synthesis of scyphostatin, a potent inhibitor of neutral sphingomyelinase │ Chemistry, a European Journal │ 13 (36),10225-10238 (共著)
37.	2007/08	Stereoselective total synthesis of arenastatin A, a spongean cytotoxic depsipeptide │ Tetrahedron Letters │ 48 (40),7147-7150 (共著)
38.	2006/11	Synthesis of 15,20-triamide analogue with polar substituent on the phenyl ring of arenastatin A, an extremely potent cytotoxic spongean depsipeptide │ Bioorg. Med. Chem. │ 14 (22),7446-7457 (共著)
39.	2006/03	Cortistatins A, B, C, and D, Anti-angiogenic Steroidal Alkaloids, from the Marine Sponge Corticium simplex │ J. Am. Chem. Soc. │ 128 (10),3148-3149 (共著)
40.	2006/01	Shimalactones, neuritogenic polyketides from a marine-derived fungus Emericella variecolor GF10 │ Heterocycles │ 68 (1),111-123 (共著)
41.	2005/08	Asymmetric Synthesis by the Intramolecular Haloetherification Reaction of Ene Acetal: Discrimination of Prochiral Dienes in Cyclohexane Systems │ Chemical & Pharmaceutical Bulletin │ 53 (8),952-957 (共著)
42.	2005/08	Shimalactone A, a novel polyketide, from marine-derived fungus Emericella variecolor GF10 │ Tetrahedron │ 61 (33),8054-8058 (共著)
43.	2005/07	Efficient total synthesis of bastadin 6, an anti-angiogenic brominated tyrosine-derived metabolite from marine sponge │ Tetrahedron │ 61 (30),7211-7218 (共著)
44.	2005/03	Absolute Stereo-structure of Kendarimide A, a Novel MDR Modulator, from a Marine Sponge │ Heterocycles │ 65 (3),563-578 (共著)
45.	2004/11	Asymmetric Desymmetrization Based on an Intramolecular Haloetherification: A Highly Effective and Recyclable Chiral Nonracemic Auxiliary, 2-exo-Methyl-3-endo-phenyl-5-norbornene-2-carboxaldehyde, for meso-1,3- and meso-1,4-Diols │ Chemistry - A European Journal │ 10 (21),5386-5397 (共著)
46.	2004/10	Structure-actuvity Relationship of Anti-malarial Spongean Peroxides Having a 3-Methoxy-1,2-dioxane Structure │ Bioorganic & Medicinal Chemistry │ 12 (20),5297-5307 (共著)
47.	2003/01	Kinetically Controlled Optical Resolution of Racemic Norbornene Aldehyde Derivatives │ Chirality │ 15 (1),60-67 (共著)
48.	2002/01	Concise asymmetric synthesis of a model compound, (4S,5S,6S)-6-(2,2-dimethoxy) ethyl-4,5-epoxy-6-hydroxy-2-cyclohexenone, for the cyclohexenone core of scyphostatin │ Tetrahedron Lett. │ 43,4825-4828 (共著)
49.	2000/12	Asymmetric Desymmetrization of Saturated and Unsaturated meso-1,2-Diols │ Tetrahedron │ 56 (52),10141-10151 (共著)
50.	2000/03	Optical Resolution of Racemic Norbornene Aldehydes: Kinetically Controlled Intramolecular Haloetherification of Ene Acetals │ Tetrahedron Letters │ 41 (11),1829-1832 (共著)
51.	1998/10	Desymmetrization of Unsaturated meso-1,2-Diols via An Intramolecular Haloetherification of Ene Acetals: A Remarkable Kinetic Control │ Tetrahedron Letters │ 39 (40),7309-7312 (共著)