Researcher Database

（Last updated : 2024-11-05 12:46:35）　

SHIRAKO SAKI

Department / Course College of Life Sciences Department of Biomedical Sciences

Title / Position Assistant Professor

Academic background
1.	2020/03 Degree Acquisition	│ Kyoto University Ph.D. (Agriculture)
2.	～2020/03	Doctorial Course │ Division of Applied Biosciences │ Graduate School of Agriculture │ Kyoto University │ Completed
3.	～2017/03	Master Course │ Division of Applied Biosciences │ Graduate School of Agriculture │ Kyoto University │ Completed
4.	～2015/03	Department of Food Sciences and Nutritional Health │ Faculty of Life and Environmental Sciences │ Kyoto Prefectural University │ Graduated

Business career
1.	2020/04/01	Assistant Professor │ College of Life Sciences │ Ritsumeikan University

Qualification and license
1.	2015	Dietitian
2.	2015	Registered Dietitian

Subject of research
1.	Comprehensive analysis of herbal medicine-derived peptides.

Research summary
Comprehensive analysis of herbal medicine-derived bioactive peptides. It was initially believed that all the protein (peptide) in foods are degraded into amino acids during digestion and absorption processes. However, it has been demonstrated that some peptides can resist to protease digestion and can be absorbed into blood circulation system to exert physiological activities, such as anti-inflammatory effect, hepato-protective effect, attenuation of dysbiosis, and so on. These peptides are referred to as “bioactive peptide”. (Japanese) Kampo medicine is known to be effective for treatment or prevention of some diseases. There are some reports on identification of active compound and its mechanism. However, there are no reports on bioactive peptide in Kampo medicine or herbal medicine. Therefore, the aim of my study is to find herbal medicine-derived bioactive peptide and to elucidate its potential mechanism for treatment or prevention of related diseases. I also study on bioactive peptide from functional foods.

Present specialized field
Analytical chemistry, Food science, Natural medicines (Keyword：Peptide、 (Japanese) Kampo medicine、 Herbal medicine、 Functional food、 Anti-inflammation)

Books
1.	2021/12/10	Pyroglutamyl peptides in Japanese fermented foods and protein hydrolysate enhance production of host-antimicrobial peptides and ameliorate microbial imbalance │ Nutrition and Functional Foods in Boosting Digestion, Metabolism and Immune Health │ ,pp.255-265 (Co-authored)

Papers
1.	2024/04/03	Atractylodin, β-eudesmol, and (+)-hinesol in Atractylodes chinensisrhizomes improve glomerular injuries in high immunoglobulin A mice │ Functional Foods in Health and Disease │ 14 (4),pp.219-231 (Co-authored)
2.	2024/03/10	Fatty acids in Plantago asiatica seeds are responsible for the production of the pro-inflammatory mediator nitric oxide │ Bioactive Compounds in Health and Disease │ 7 (5),pp.233-244 (Co-authored)
3.	2023/08/16	Hydrophobic constituents of Polygonum multiflorum roots promote renal erythropoietin expression in healthy mice │ Journal of Natural Medicines │ (Co-authored)
4.	2023/06/28	Identification of Anti-Inflammatory Compounds from Peucedanum praeruptorum Roots by Using Nitric Oxide-Producing Rat Hepatocytes Stimulated by Interleukin 1β │ Molecules │ 28 (13),pp.5076 (Co-authored)
5.	2022/08/16	Anti-inflammatory effects of hydrophobic constituents in the extract of the root cortex of Paeonia suffruticosa │ Bioactive Compounds in Health and Disease │ 5 (8),pp.160-173 (Co-authored)
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Academic conference presentation
1.	2023/07/22	Improvement of insulin sensitivity and inhibition of hepatic gluconeogenesis by components in bitter melon fruits (International Diabetes Federation Western Pacific Region Congress 2023)
2.	2022/08/04	Comprehensive analysis of Hydrophilic Fraction of Crude Drug Extracts based on digestion and absorption processes (2022 General Assembly of the European Society of Medicine (ESMED General Assembly))
3.	2022/07/10	Constituents that suppress nitric oxide production in green perilla and red perilla (The 30th Annual Meeting of International Congress on Nutrition and Integrative Medicines)
4.	2022/07/09	LC-MS/MS analyses of in vitro protease digests of ECLM, EAS, and OPLEF (The 30th Annual Meeting of International Congress on Nutrition and Integrative Medicines)
5.	2022/06/08	Determination of hydrophobic constituents of the root of Polygonum multiflorum using LC-MS/MS and their anti-inflammatory effect in rat hepatocytes (70th ASMS Conference on Mass Spectrometry and Allied Topics)
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Winning science prize
1.	2022/07/09	International Congress on Nutrition and Integrative Medicine Young Investigator Award 2022
2.	2019/12	ICoFF2019 Young Investigator Award (Pyroglutamyl peptides with anti-obesity, which are distributed in Japanese fermented foods, regulate ERK phosphorylation through GPR109A and GPR81)
3.	2018/11	2018 Global Food Science Student Competition (GFSSC) in Jiangnan University（中国）口頭発表銅賞 (Administration of pyroGlu-Leu, distributed in fermented foods, increases antimicrobial peptides, Rattusin, and improves high fat diet induced-dysbiosis in rats)
4.	2017/10	ISNFF2017 Poster Award (First place) (Oral administration of pyroGlu-Leu, widely distributed in protein hydrolysates and fermented foods, increases antimicrobial peptides in rat small intestine)
5.	2015/11	ICoFF2015 Poster Award (Identification of glutathione-binding protein in human plasma after supplementation of glutathione)

Grants-in-Aid for Scientific Research -KAKENHI-
1.	2022/04/01 ～ 2025/03/31	Effect of decarboxylated amino acids found in Ziziphus jujuba for the improvement of frailty. │ Early-Career Scientists