Researcher Database

（Last updated : 2024-02-28 17:13:01）

HAYANO Toshiya

Department / Course College of Life Sciences Department of Biomedical Sciences

Title / Position Professor

Other Affiliations
1.	Graduate School of Life Sciences
2.	Research Organization of Science and Technology The Institute of Science and Engineering
3.	Research Organization of Science and Technology Institute of Advanced Research for Sport and Health Science

Academic background
1.	～1987/03	Master Course │ Department of Biophysics and Biochemistry │ Graduate School, Division of Science │ The University of Tokyo │ Completed
2.		│ The University of Tokyo Ph.D. in Science
3.	～1985/03	Department of Biochemistry │ Faculty of Science │ The University of Tokyo │ Graduated

Research activities
1.		The Molecular Biology Society of Japan

Research summary
Elucidation of human ribosome biosynthesis process I am engaged in the research on the relationship of the human ribosome, unknown cell functions and diseases by clarifying the whole human ribosome biosynthesis process using proteomic analysis.

Present specialized field
Proteomics (Keyword：Proteomics, Biochemistry, Molecular biology)

Papers
1.	2022/07/25	Coagulation factors promote brown adipose tissue dysfunction and abnormal systemic metabolism in obesity │ iScience │ (Co-authored)
2.	2022/07/24	Proteomic analysis of nascent polypeptide chains that potentially induce translational pausing during elongation │ Biosci Biotechnol Biochem . │ (Co-authored)
3.	2021	Distinct RNA polymerase transcripts direct the assembly of phase-separated DBC1 nuclear bodies in different cell lines │ Molecular Biology of the Cell │ 32 (21) (Co-authored)
4.	2019/09	LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA │ Nucleic Acids Res. │ 47,pp.10357-10372 (Co-authored)
5.	2017/09	Hyperactive mTOR induces neuroendocrine differentiation in prostate cancer cell with concurrent up-regulation of IRF1 │ Prostate │ 77 (15),pp.1489-1498 (Co-authored)
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Academic conference presentation
1.	2024/01/30	Functional analysis of barrier-to-autointegration factor-like protein (BAF-L) (the 7th International KBMSS Symposium)
2.	2023/11/28	Characterization of abnormal phase separation structure formed by ALS-linked FUS mutants
3.	2023/11/28	Involvement of HP1 in functional expression of BAF
4.	2023/11/28	Possible involvement of barrier-to-autointegration factor (BAF) in DNA damage repair
5.	2023/11/28	Construction of a platform to search for a therapeutic drug candidate for Néstor-Guillermo progeria syndrome (NGPS)
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Acquisition patent
1.		Co-expression system of protein disulfide isomerase gene and useful polypeptide gene and process for producing the polypeptide using its system
2.		Isolated genes encoding peptidyl prolyl-cis.trans-isomerase and plasmids comprising said genes
3.		Recombinant co-expression system of protein disulfide isomerase gene, yeast receptor protein ERD2 gene and a foreign product polypeptide gene, and a process for producing the foreign polypeptide using such system